Back to Search
Start Over
Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis
- Source :
- Neural Regeneration Research, Vol 12, Iss 6, Pp 953-958 (2017)
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Medknow Publications, 2017.
-
Abstract
- Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that ganoderma lucidum polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects.
Details
- Language :
- English
- ISSN :
- 16735374
- Volume :
- 12
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Neural Regeneration Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9407979681904415bf73d4d806e7364a
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/1673-5374.208590