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Controlling brain dynamics: Landscape and transition path for working memory.
- Source :
- PLoS Computational Biology, Vol 19, Iss 9, p e1011446 (2023)
- Publication Year :
- 2023
- Publisher :
- Public Library of Science (PLoS), 2023.
-
Abstract
- Understanding the underlying dynamical mechanisms of the brain and controlling it is a crucial issue in brain science. The energy landscape and transition path approach provides a possible route to address these challenges. Here, taking working memory as an example, we quantified its landscape based on a large-scale macaque model. The working memory function is governed by the change of landscape and brain-wide state switching in response to the task demands. The kinetic transition path reveals that information flow follows the direction of hierarchical structure. Importantly, we propose a landscape control approach to manipulate brain state transition by modulating external stimulation or inter-areal connectivity, demonstrating the crucial roles of associative areas, especially prefrontal and parietal cortical areas in working memory performance. Our findings provide new insights into the dynamical mechanism of cognitive function, and the landscape control approach helps to develop therapeutic strategies for brain disorders.
- Subjects :
- Biology (General)
QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 1553734X and 15537358
- Volume :
- 19
- Issue :
- 9
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.93dcac626f424e1dbcd2b392b92324a9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1011446&type=printable