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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights

Authors :
Olusegun Isaac Alatise
Gregory C. Knapp
Avinash Sharma
Walid K. Chatila
Olukayode A. Arowolo
Olalekan Olasehinde
Olusola C. Famurewa
Adeleye D. Omisore
Akinwumi O. Komolafe
Olaejinrinde O. Olaofe
Aba I. Katung
David E. Ibikunle
Adedeji A. Egberongbe
Samuel A. Olatoke
Sulaiman O. Agodirin
Olusola A. Adesiyun
Ademola Adeyeye
Oladapo A. Kolawole
Akinwumi O. Olakanmi
Kanika Arora
Jeremy Constable
Ronak Shah
Azfar Basunia
Brooke Sylvester
Chao Wu
Martin R. Weiser
Ken Seier
Mithat Gonen
Zsofia K. Stadler
Yelena Kemel
Efsevia Vakiani
Michael F. Berger
Timothy A. Chan
David B. Solit
Jinru Shia
Francisco Sanchez-Vega
Nikolaus Schultz
Murray Brennan
J. Joshua Smith
T. Peter Kingham
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is important for early detection and treatment. Here, the authors use a multigene next-generation sequencing panel to identify genomic differences in Nigerian CRCs compared to those from TCGA and MSKCC cohorts.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.939275ce40494796b17543b64bb2bcce
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-27106-w