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Insulin and bone health in young adults: The mediator role of lean mass.
- Source :
- PLoS ONE, Vol 12, Iss 3, p e0173874 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- BACKGROUND:The positive relationship between lean mass (LM) and bone health is well known, but a positive association between insulin and LM has also been described. Insulin has some anabolic properties on bone through the stimulation of osteoblast differentiation, yet the role of LM as a confounder or mediator in this relationship remains uncertain. OBJECTIVE:To examine whether the association between insulin levels and bone health is mediated by LM. METHODS:A cross-sectional study was conducted at the Castilla La Mancha University (Spain) involving 466 young adults (113 young men; 19.5±2.3 years). LM and total-body bone mineral content (BMC) were measured by dual energy x-ray absorptiometry, and insulin was measured in fasting serum samples. RESULTS:Young adults with high total LM had higher values of total-body BMC than their peers after controlling for age and sex, this relationship persisted after adjusting for insulin levels (p0.05) as indicated by Sobel test values for indirect effect (z = 4.43; p
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9391bcdee34412bc3caacd90bdf1f6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1371/journal.pone.0173874