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High-Throughput Toxicity and Phenotypic Screening of 3D Human Neural Progenitor Cell Cultures on a Microarray Chip Platform
- Source :
- Stem Cell Reports, Vol 7, Iss 5, Pp 970-982 (2016)
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- A 3D cell culture chip was used for high-throughput screening of a human neural progenitor cell line. The differential toxicity of 24 compounds was determined on undifferentiated and differentiating NPCs. Five compounds led to significant differences in IC50 values between undifferentiated and differentiating cultures. This platform has potential use in phenotypic screening to elucidate molecular toxicology on human stem cells.
Details
- Language :
- English
- ISSN :
- 22136711
- Volume :
- 7
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Stem Cell Reports
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.93896739bb0749189e37a02909ac5839
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.stemcr.2016.10.001