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Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy

Authors :
Alejandro David Bendala Estrada
Jorge Calderón Parra
Eduardo Fernández Carracedo
Antonio Muiño Míguez
Antonio Ramos Martínez
Elena Muñez Rubio
Manuel Rubio-Rivas
Paloma Agudo
Francisco Arnalich Fernández
Vicente Estrada Perez
María Luisa Taboada Martínez
Anxela Crestelo Vieitez
Paula Maria Pesqueira Fontan
Marta Bustamante
Santiago J. Freire
Isabel Oriol-Bermúdez
Arturo Artero
Julián Olalla Sierra
María Areses Manrique
H. Francisco Javier Carrasco-Sánchez
Vanessa Carolina Vento
Gema María García García
Pablo Cubero-Morais
José-Manuel Casas-Rojo
Jesús Millán Núñez-Cortés
Source :
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-23 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Since December 2019, the COVID-19 pandemic has changed the concept of medicine. This work aims to analyze the use of antibiotics in patients admitted to the hospital due to SARS-CoV-2 infection. Methods This work analyzes the use and effectiveness of antibiotics in hospitalized patients with COVID-19 based on data from the SEMI-COVID-19 registry, an initiative to generate knowledge about this disease using data from electronic medical records. Our primary endpoint was all-cause in-hospital mortality according to antibiotic use. The secondary endpoint was the effect of macrolides on mortality. Results Of 13,932 patients, antibiotics were used in 12,238. The overall death rate was 20.7% and higher among those taking antibiotics (87.8%). Higher mortality was observed with use of all antibiotics (OR 1.40, 95% CI 1.21–1.62; p

Details

Language :
English
ISSN :
14712334
Volume :
21
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.934fba04e7b4410bb5505c10cacb408
Document Type :
article
Full Text :
https://doi.org/10.1186/s12879-021-06821-1