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The RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly

Authors :
Gerald Ryan R. Aquino
Philipp Hackert
Nicolai Krogh
Kuan-Ting Pan
Mariam Jaafar
Anthony K. Henras
Henrik Nielsen
Henning Urlaub
Katherine E. Bohnsack
Markus T. Bohnsack
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Early steps of large 60S ribosomal subunit biogenesis are not well understood. Here, the authors combine biochemical experiments with protein-RNA crosslinking and mass spectrometry to show that the RNA helicase Dbp7 is key player during early 60S ribosomal assembly. Dbp7 regulates a series of events driving compaction of domain V/VI in early pre60S ribosomal particles.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.9348e45ad3e4a0888725af478868ba9
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-26208-9