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Total Syntheses of Chloropupukeananin and Its Related Natural Products
- Source :
- Organics, Vol 3, Iss 3, Pp 304-319 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Chloropupukeananin is a natural product that inhibits HIV-1 replication and has antitumor activity. Its structure consists of a chlorinated tricyclo[4.3.1.03,7]decane core skeleton with an array of highly oxidized multifunctional groups. In the biosynthesis of chloropupukeananin, (+)-iso-A82775C and (−)-maldoxin are employed as biosynthetic precursors for the intermolecular Diels–Alder and carbonyl–ene reactions, followed by the migration of the p-orcellinate group. Chloropupukeanolides and chloropestolides are intermediates and isomers in biosynthesis; their unique chemical structures and biosynthetic pathways have attracted significant attention from synthetic chemists. In this review, I present the synthetic studies on chloropupukeananin and its related compounds that have been conducted thus far.
Details
- Language :
- English
- ISSN :
- 2673401X
- Volume :
- 3
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Organics
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.9309bd712241729901e46099f38512
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/org3030023