Comparison of Postprandial Insulin Levels in Withania Coagulans and Liraglutide Treated Diabetic Rats

Objective: To investigate and compare the antidiabetic effect of withania coagulans and Liraglutide on serum postprandial insulin levels in streptozotocin induced diabetes in rats. Study Design: Randomized Control Trial. Place and Duration of Study: The study was conducted from 1 April 2016 to 31 March 2017 at Islamic International Medical College in collaboration with National Institute of Health Islamabad. Materials and Methods: Total 40 male Sprague dawley rats were randomly divided into two groups; Group A (n=10) and Experimental Group (n=30). Group A was given normal diet for 5 days whereas experimental group was given normal diet plus streptozotocin (30mg/kg/day) intraperitoneally for 5 days and diabetes was confirmed in experimental group by fasting blood glucose (mg/dl). Experimental group was further divided into B (Diabetic control), C (Withania coagulans treated) and D (Liraglutide treated). First sampling group A and B was done after 5 days. Group C were given Withania coagulans and Group D were given Liraglutide along with normal diet for 30 days. Second sampling (fasting blood glucose, postprandial glucose and insulin level) was done from group C and D. Results: Fasting blood glucose of group C (98 mg/dl ± 1.80) was significantly reduced than group D (102 mg/dl ± 2.04). Postprandial glucose and insulin levels of Group D (163 mg/dl ± 3.95 and 6.06 μU/ml ±0.17) were significantly decreased and increased as compared to Group C PPG (183 mg/dl ± 6.30) and insulin level (5.54 μU/ml ± 0.23). Conclusion: Withania Coagulans significantly improves postprandial insulin levels as compared to liraglutide.