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Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.92c7e083594457b9d565bc9efb1942
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-09641-9