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Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans

Authors :
Anna Borup
Ida Donkin
Mariëtte R. Boon
Martin Frydland
Borja Martinez-Tellez
Annika Loft
Sune H. Keller
Andreas Kjaer
Jesper Kjaergaard
Christian Hassager
Romain Barrès
Patrick C. N. Rensen
Christina Christoffersen
Source :
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Abstract The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism. ApoM deficiency in mice is associated with increased vascular permeability, brown adipose tissue (BAT) mass and activity, and protection against obesity. In the current study, we explored the connection between plasma apoM/S1P levels and parameters of BAT as measured via 18F-FDG PET/CT after cold exposure in humans. Fixed (n = 15) vs personalized (n = 20) short-term cooling protocols decreased and increased apoM (− 8.4%, P = 0.032 vs 15.7%, P

Subjects

Subjects :
Medicine
Science

Details

Language :
English
ISSN :
20452322
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.928242ef3141f18c4d97ecb075955f
Document Type :
article
Full Text :
https://doi.org/10.1038/s41598-022-21938-2