Back to Search Start Over

Reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl

Authors :
European Food Safety Authority (EFSA)
Giulia Bellisai
Giovanni Bernasconi
Alba Brancato
Luis Carrasco Cabrera
Lucien Ferreira
German Giner
Luna Greco
Samira Jarrah
Aija Kazocina
Renata Leuschner
Jose Oriol Magrans
Ileana Miron
Stefanie Nave
Ragnor Pedersen
Hermine Reich
Silvia Ruocco
Miguel Santos
Alessia Pia Scarlato
Anne Theobald
Benedicte Vagenende
Alessia Verani
Source :
EFSA Journal, Vol 19, Iss 8, Pp n/a-n/a (2021)
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

Abstract In compliance with Article 43 of Regulation (EC) No 396/2005, EFSA received from the European Commission a mandate to provide its reasoned opinion on the toxicological properties and maximum residue levels (MRLs) for the benzimidazole substances carbendazim and thiophanate‐methyl. Specifically, EFSA was asked to assess whether thiophanate‐methyl or carbendazim have clastogenic potential and, in case clastogenic potential can be excluded, to derive toxicological reference values necessary for consumer risk assessment and assessment of maximum residue levels (MRLs). Although these active substances are no longer authorised within the European Union, MRLs were established by the Codex Alimentarius Commission (codex maximum residue limits; CXLs), and import tolerances are in place. Based on the assessment of the available data, toxicological reference values and MRL proposals were derived and a consumer risk assessment was carried out. Some information required by the regulatory framework was found to be missing and a possible acute risk to consumers was identified. Hence, the consumer risk assessment is considered indicative only, all MRL proposals derived by EFSA still require further consideration by risk managers and measures for reduction of the consumer exposure should also be considered.

Details

Language :
English
ISSN :
18314732
Volume :
19
Issue :
8
Database :
Directory of Open Access Journals
Journal :
EFSA Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.923ca66f5d34c73a94023bdcd28a0f5
Document Type :
article
Full Text :
https://doi.org/10.2903/j.efsa.2021.6773