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MicroRNAs promote skeletal muscle differentiation of mesodermal iPSC-derived progenitors

Authors :
Giorgia Giacomazzi
Bryan Holvoet
Sander Trenson
Ellen Caluwé
Bojana Kravic
Hanne Grosemans
Álvaro Cortés-Calabuig
Christophe M. Deroose
Danny Huylebroeck
Said Hashemolhosseini
Stefan Janssens
Elizabeth McNally
Mattia Quattrocelli
Maurilio Sampaolesi
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Mesodermal iPSC-derived progenitors (MiPs) can regenerate both skeletal and cardiac muscle. Here, the authors show that a microRNA cocktail stimulates skeletal muscle differentiation and that human MiPs can engraft into striated muscle in mice.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.92068e1fa5d401cb076a3ec19008468
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-017-01359-w