Back to Search Start Over

Colonization with extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE) in healthcare and community settings in Botswana: an antibiotic resistance in communities and hospitals (ARCH) study

Authors :
Naledi Mannathoko
Mosepele Mosepele
Robert Gross
Rachel M. Smith
Kevin Alby
Laurel Glaser
Melissa Richard-Greenblatt
Rebekah Dumm
Aditya Sharma
Anne Jaskowiak-Barr
Leigh Cressman
Kgotlaetsile Sewawa
Laura Cowden
Emily Reesey
Dimpho Otukile
Giacomo M. Paganotti
Margaret Mokomane
Ebbing Lautenbach
Source :
International Journal of Infectious Diseases, Vol 122, Iss , Pp 313-320 (2022)
Publication Year :
2022
Publisher :
Elsevier, 2022.

Abstract

Objectives: Although extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE) are a global challenge, data on these organisms in low- and middle-income countries are limited. In this study, we sought to characterize colonization data critical for greater antibiotic resistance surveillance efforts. Methods: This study was conducted in three hospitals and six clinics in Botswana. We conducted ongoing surveillance of adult patients in hospitals and clinics and adults and children in the community. All participants underwent rectal swab sampling to identify ESCrE and CRE. Results: Enrollment occurred from January 15, 2020, to September 4, 2020, but paused from April 2, 2020, to May 21, 2020, because of a countrywide COVID-19 lockdown. Of 5088 individuals approached, 2469 (49%) participated. ESCrE colonization prevalence was 30.7% overall (43% for hospital participants, 31% for clinic participants, 24% for adult community participants, and 26% for child community participants) (P

Details

Language :
English
ISSN :
12019712
Volume :
122
Issue :
313-320
Database :
Directory of Open Access Journals
Journal :
International Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.92041b160ec14f8ca73e08f45ea6990c
Document Type :
article
Full Text :
https://doi.org/10.1016/j.ijid.2022.06.004