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Sativa seeds against Schistosoma mansoni different stages
- Source :
- Memorias do Instituto Oswaldo Cruz, Vol 100, Iss 2, Pp 205-211 (2005)
- Publication Year :
- 2005
- Publisher :
- Fundação Oswaldo Cruz (FIOCRUZ), 2005.
-
Abstract
- The schistosomicidal properties of Nigella sativaseeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which have a role in protection of adult worms against host oxidant killing; as well as some enzymes of glucose metabolism; which have a crucial role in the survival of adult worms inside their hosts. The data revealed that the used drug induce an oxidative stress against adult worms which indicated by a decrease in the activities of both antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the antischistosomal potency of the used drug.
Details
- Language :
- English
- ISSN :
- 00740276 and 16788060
- Volume :
- 100
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.91f581304b9449649d1e1647f9e390f3
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/S0074-02762005000200016