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Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
- Source :
- Journal of Saudi Chemical Society, Vol 25, Iss 6, Pp 101259- (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance. Furthermore, 2-pyridones are a different category of pharmacophores that exhibit several biological activities. Results: The 2-pyridones substrates are synthetically multilateral, where they can be used to synthesize a wide range of heterocyclic compounds and as a drug synthesis raw material. Therefore, it was the purpose of this review to evaluate the pharmacological properties of various substituted 2-pyridone systematically and collates these findings to be used as a guide for future structure–activity relationship and mode of action studies. Conclusion: Taken together, we demonstrate that the fused 2-pyridone is a versatile scaffold for biological applications.
Details
- Language :
- English
- ISSN :
- 13196103
- Volume :
- 25
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Saudi Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.91f20740abf341e79c0da9f24975e094
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jscs.2021.101259