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Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Acute kidney injury is frequent, often fatal and can leave survivors with chronic kidney disease. Here the authors show that tubular cell polyploidy reduces early fatality sustaining residual function but promotes chronic kidney disease, which can be prevented by blocking YAP1
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.91d01abb8dc48d881536bd29de595fa
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-33110-5