Back to Search Start Over

Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid

Authors :
L. P. Sizyakina
A. I. Sergeeva
I. I. Andreeva
Source :
Медицинский вестник Юга России, Vol 12, Iss 1, Pp 68-73 (2021)
Publication Year :
2021
Publisher :
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation, 2021.

Abstract

Objective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days. The parameters of the innate and adaptive immune response were studied before and two weeks after the end of the course. The skin condition was assessed by dermatoscopy (Aramo Smart Lite 300, Southern Korea).Results. The clinical effect of the course of procedures was reflected in the subjective improvement in the appearance. The improvement was confirmed by hardware analysis, which recorded an increase in hydration, a smoothing of the skin relief, and a decrease in the depth of wrinkles. At the end of the course, redistribution of lymphocyte populations towards natural killer cells and B-lymphocytes was revealed with a decrease in the total number of T cells. The antibody production of immunoglobulins of classes M and G was increased, the serum content of Ig A and IgE was reduced, the number of both T-effectors and T-lymphocytes with immunosuppressive activity increased. Changes in the neutrophil system were characterized by the inhibition of the production of reactive oxygen intermediates; the dynamics of the expression of Toll-like receptors by monocytes was ambiguous.Conclusion. The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes.

Details

Language :
English, Russian
ISSN :
22198075 and 26187876
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Медицинский вестник Юга России
Publication Type :
Academic Journal
Accession number :
edsdoj.91a39c3c452347a898cee7b1a5ee1637
Document Type :
article
Full Text :
https://doi.org/10.21886/2219-8075-2021-12-1-68-73