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Neuroimaging in Nonsyndromic Craniosynostosis: Key Concepts to Unlock Innovation

Authors :
Camilla Russo
Ferdinando Aliberti
Ursula Pia Ferrara
Carmela Russo
Domenico Vincenzo De Gennaro
Adriana Cristofano
Anna Nastro
Domenico Cicala
Pietro Spennato
Mario Quarantelli
Marco Aiello
Andrea Soricelli
Giovanni Smaldone
Nicola Onorini
Lucia De Martino
Stefania Picariello
Stefano Parlato
Peppino Mirabelli
Lucia Quaglietta
Eugenio Maria Covelli
Giuseppe Cinalli
Source :
Diagnostics, Vol 14, Iss 17, p 1842 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Craniosynostoses (CRS) are caused by the premature fusion of one or more cranial sutures, with isolated nonsyndromic CRS accounting for most of the clinical manifestations. Such premature suture fusion impacts both skull and brain morphology and involves regions far beyond the immediate area of fusion. The combined use of different neuroimaging tools allows for an accurate depiction of the most prominent clinical–radiological features in nonsyndromic CRS but can also contribute to a deeper investigation of more subtle alterations in the underlying nervous tissue organization that may impact normal brain development. This review paper aims to provide a comprehensive framework for a better understanding of the present and future potential applications of neuroimaging techniques for evaluating nonsyndromic CRS, highlighting strategies for optimizing their use in clinical practice and offering an overview of the most relevant technological advancements in terms of diagnostic performance, radiation exposure, and cost-effectiveness.

Details

Language :
English
ISSN :
20754418
Volume :
14
Issue :
17
Database :
Directory of Open Access Journals
Journal :
Diagnostics
Publication Type :
Academic Journal
Accession number :
edsdoj.912fa28d8125413c9b22943c681b4721
Document Type :
article
Full Text :
https://doi.org/10.3390/diagnostics14171842