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The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia

Authors :
Sara Mascheretti
Valentina Riva
Bei Feng
Vittoria Trezzi
Chiara Andreola
Roberto Giorda
Marco Villa
Ginette Dionne
Simone Gori
Cecilia Marino
Andrea Facoetti
Source :
Brain Sciences, Vol 10, Iss 12, p 993 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e., DYX1C1, DCDC2, KIAA0319, ROBO1 and GRIN2B) using a multiple-predictor/multiple-mediator framework. Our results show that rapid auditory and visual motion processing are mediators in the pathway from ROBO1-rs9853895 to reading. Specifically, the T/T genotype group predicts impairments in rapid auditory and visual motion processing which, in turn, predict poorer reading skills. Our results suggest that ROBO1 is related to reading via multisensory temporal processing. These findings support the use of EPs as an effective approach to disentangling the complex pathways between candidate genes and behavior.

Details

Language :
English
ISSN :
20763425
Volume :
10
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Brain Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.911f255a2ab745648b7ae4592d5fdce0
Document Type :
article
Full Text :
https://doi.org/10.3390/brainsci10120993