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p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.910a2213640443158f5902af774dca02
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-18838-2