Epithelioma cuniculatum arising on a preexisting wart

Epithelioma cuniculatum is a rare, well-differentiated variant of verrucous carcinoma, arising almost exclusively on foot, with a minimal incidence of metastasis. Clinically, it presents as a non-verrucous, slow growing, exophytic plaque or tumor of the plantar region with a penetration in the deep tissues. Histological examination shows a proliferation of well-differentiated keratinocytes. Conservative treatment and local excision have been utilized, but high recurrence rates have been observed. We report a case of epithelioma cuniculatum arising on the plantar aspect of foot in a 60-year old male, which arose at the site of a preexisting wart, which was managed by surgical excision.