Back to Search Start Over

Prognostic Value and Limits of Heart Rate and QT—Corrected in A Large Population

Authors :
Paolo Giovanardi
Cecilia Vernia
Sara Roversi
Enrico Tincani
Giuseppe Spadafora
Federico Silipo
Claudio Giberti
Source :
Hearts, Vol 5, Iss 2, Pp 225-235 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Background: The study aimed to compare the prognostic importance of the heart rate (HR) and QT—corrected (QTc) according to Fridericia, Framingham, and Bazett with respect to all-cause mortality in a large non-selected population. Methods: The analysis of digital electrocardiograms archived from 2008 to 2022 in the metropolitan area of Modena, Italy, was carried out. The population under study was divided into three groups based on age, and survival analysis was performed. Results: 131,627 patients were enrolled and, during the follow-up (mean 1641.4 days), all-cause mortality was 8.9%. Both HR and QTc were associated with mortality. All-cause mortality significantly increased with HR values greater than 81 BPM and QTc values greater than 440 msec in young subjects and 455 msec in old subjects (values of the 75th percentiles/optimal operating point). A Cox analysis confirmed the better prognostic value of Bazett’s QTc and HR in the whole population and in the three age-groups. Conclusion: Bazett’s method performed better than the others, but, unexpectedly, the HR had the same or an even better correlation with all-cause mortality. Since the HR is simple and readily available, its evaluation should be improved. However, QTC and HR values are difficult to define, causing many confounding factors, and further population studies are required.

Details

Language :
English
ISSN :
26733846
Volume :
5
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Hearts
Publication Type :
Academic Journal
Accession number :
edsdoj.90cc1a1f86542a8901d74f9483380c4
Document Type :
article
Full Text :
https://doi.org/10.3390/hearts5020015