Back to Search Start Over

Pro/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid

Authors :
Joanna Rog
Łukasz Łobejko
Michalina Hordejuk
Wojciech Marciniak
Róża Derkacz
Adam Kiljańczyk
Milena Matuszczak
Jan Lubiński
Miłosz Nesterowicz
Małgorzata Żendzian-Piotrowska
Anna Zalewska
Mateusz Maciejczyk
Hanna Karakula-Juchnowicz
Source :
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

Disturbances in pro/antioxidant balance emerge as a crucial element in bipolar disorder (BD). Some studies suggest that treatment effects on trace element concentration in BD. This study aimed to identify (a) the changes related to oxidative stress in BD and their relationship with trace elements engaged in pro/antioxidant homeostasis; (b) BD biomarkers using machine learning algorithm classification and regression tree (C&RT) analysis. 62 individuals with BD and 40 healthy individuals (HC) were included in the study. The concentration of pro/antioxidant state and concentration of selenium, zinc, arsenic in blood were assessed. We found a higher concentration of total antioxidant capacity, catalase, advanced oxidation protein products and a lower concentration of 4-hydroxynonenal (4-HNE), glutathione, glutathione peroxidase (GPx) in BD compared to HC. All examined trace elements were lower in the BD group compared to HC. A combination of two variables, 4-HNE (cut-off: ≤ 0.004 uM/mg protein) and GPx (cut-off: ≤ 0.485 U/mg protein), was the most promising markers for separating the BD from the HC. The area under the receiver operating characteristic curve values for C&RT was 90.5%. Disturbances in the pro/antioxidant state and concentration of trace elements of patients with BD may be a target for new therapeutic or diagnostic opportunity of BD biomarkers.

Details

Language :
English
ISSN :
16625099
Volume :
17
Database :
Directory of Open Access Journals
Journal :
Frontiers in Molecular Neuroscience
Publication Type :
Academic Journal
Accession number :
edsdoj.90af8e54416b4c208cbb77f24615f4e5
Document Type :
article
Full Text :
https://doi.org/10.3389/fnmol.2024.1441575