CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis

Authors :: Can Yang
Zhiyuan Feng
Hong Deng
Lu Dai
Ling He
Linlin Yin
Jing Zhao
Source :: BMC Neuroscience, Vol 23, Iss 1, Pp 1-11 (2022)
Publication Year :: 2022
Publisher :: BMC, 2022.
Abstract: Highlights 1. Pathologically impaired periventricular white matter was observed in NEC neonatal rats. 2. Hypoxic-ischemic brain injury can also lead to intestinal inflammation. 3. CXCL1 and CXCR2 were significantly upregulated in intestinal and brain tissues in NEC, HIBI, and NEC+HIBI rats compared to the normal group. 4. Compared with the HIBI group, CXCL1 and CXCR2 expression continued to increase in NEC+HIBI rats.

Subjects :: White matter injury
Necrotizing enterocolitis
Gut–Brain axis
CXCL1
CXCR2
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurophysiology and neuropsychology
QP351-495

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