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PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer: a systematic review and meta-analysis of randomized clinical trials

PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer: a systematic review and meta-analysis of randomized clinical trials

Authors :
Francisco Cezar Aquino de Moraes
Eric Pasqualotto
Lucca Moreira Lopes
Maria Eduarda Cavalcanti Souza
Anna Luíza Soares de Oliveira Rodrigues
Artur Menegaz de Almeida
Carlos Stecca
Marianne Rodrigues Fernandes
Ney Pereira Carneiro dos Santos
Source :
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Background Paclitaxel and carboplatin is the standard chemotherapy for the treatment of advanced or recurrent endometrial cancer. However, the benefit of adding programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors to chemotherapy is still unclear. Method We searched PubMed, Scopus, Cochrane, and Web of Science databases for randomized controlled trials that investigated PD-1/PD-L1 inhibitors plus carboplatin and paclitaxel compared with carboplatin and paclitaxel in primary advanced or recurrent endometrial cancer. We computed hazard ratios (HRs) or risk ratios (RRs) for binary endpoints, with 95% confidence intervals (CIs). We used DerSimonian and Laird random-effect models for all endpoints. Heterogeneity was assessed using I2 statistics. R, version 4.2.3, was used for statistical analyses. Results A total of three studies and 1,431 patients were included. Compared with carboplatin plus paclitaxel-based chemotherapy, progression-free survival (PFS) rate (HR 0.32; 95% CI 0.23–0.44; p

Details

Language :
English
ISSN :
14712407
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Cancer
Publication Type :
Academic Journal
Accession number :
edsdoj.9067428040ba4426a180825792d8557a
Document Type :
article
Full Text :
https://doi.org/10.1186/s12885-023-11654-z