Impact of bone density and integrated screw configuration on standalone anterior lumbar interbody construct strength

Background: In anterior lumbar interbody fusion (ALIF), the use of integrated screws is attractive to surgeons because of the ease of implantation and no additional profile. However, the number and length of screws necessary for safe and stable implantation in various bone densities is not yet fully understood. The current study aims to determine how important both length and number of screws are for stability of ALIFs. Methods: Three bone models with densities of 10, 15, and 20 pounds per cubic foot (PCF) were chosen as surrogates. These were instrumented using the Z-Link lumbar interbody system with either 2, 3, or 4 integrated 4.5 × 20 mm screws or 4.5 × 25 mm screws (Zavation, LLC, Flowood, MS). The bone surrogates were tested with loading conditions resulting in spine extension to measure construct stiffness and peak force. Results: The failure load of the construct was influenced by the length of screws (p=.01) and density of the bone surrogate (p