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Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure

Authors :
Mallory Paynich Murray
Isaac Engel
Grégory Seumois
Sara Herrera-De la Mata
Sandy Lucette Rosales
Ashu Sethi
Ashmitaa Logandha Ramamoorthy Premlal
Goo-Young Seo
Jason Greenbaum
Pandurangan Vijayanand
James P. Scott-Browne
Mitchell Kronenberg
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and after antigenic stimulation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8fd3eb5a36ea4cf5a286dfc60609479d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21574-w