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Helicobacter pylori Eradication Modulates Aberrant CpG Island Hypermethylation in Gastric Carcinogenesis
- Source :
- The Korean Journal of Gastroenterology, Vol 68, Iss 5, Pp 253-259 (2016)
- Publication Year :
- 2016
- Publisher :
- Jin Publishing & Printing Co., 2016.
-
Abstract
- Background : /Aims: Helicobacter pylori infection induces aberrant DNA methylation in gastric mucosa. We evaluated the long-term effect of H. pylori eradication on promotor CpG island hypermethylation in gastric carcinogenesis. Methods : : H. pylori-positive patients with gastric adenoma or early gastric cancer who underwent endoscopic resection were enrolled. According to H. pylori eradication after endoscopic resection, the participants were randomly assigned to H. pylori eradication or non-eradication group. H. pylori-negative gastric mucosa from normal participants provided the normal control. CpG island hypermethylation of tumor-related genes (p16, CDH1, and RUNX-3) was evaluated by quantitative MethyLight assay in non-tumorous gastric mucosa. The gene methylation rate and median values of hypermethylation were compared after one year by H. pylori status. Results : : In H. pylori-positive patients, hypermethylation of p16 was found in 80.6%, of CDH1 in 80.6%, and of RUNX-3 in 48.4%. This is significantly higher than normal control (p16, 10%; CDH1, 44%; RUNX-3, 16%) (p
- Subjects :
- Helicobacter pylori
CpG hypermethylation
p16
CDH1
Carcinogenesis
Medicine
Subjects
Details
- Language :
- English, Korean
- ISSN :
- 15989992
- Volume :
- 68
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- The Korean Journal of Gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8fa3a2c23ff46f99bd3c8576f2c3f6a
- Document Type :
- article
- Full Text :
- https://doi.org/10.4166/kjg.2016.68.5.253