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Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers

Authors :
Cristina Torrisi
Giuseppe Antonio Malfa
Rosaria Acquaviva
Francesco Castelli
Maria Grazia Sarpietro
Source :
Membranes, Vol 12, Iss 3, p 283 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The interactions of drugs with cell membranes are of primary importance for several processes involved in drugs activity. However, these interactions are very difficult to study due to the complexity of biological membranes. Lipid model membranes have been developed and used to gain insight into drug–membrane interactions. In this study, the interaction of protocatechuic acid ethyl ester, showing radical-scavenging activity, antimicrobial, antitumor and anti-inflammatory effects, with model membranes constituted by multilamellar vesicles and monolayers made of DMPC and DSPC, has been studied. Differential scanning calorimetry and Langmuir–Blodgett techniques have been used. Protocatechuic acid ethyl ester interacted both with MLV and monolayers. However, a stronger interaction of the drug with DMPC-based model membranes has been obtained. The finding of this study could help to understand the protocatechuic acid ethyl ester action mechanism.

Details

Language :
English
ISSN :
20770375
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Membranes
Publication Type :
Academic Journal
Accession number :
edsdoj.8e7ef3f7ee7045328e81dbc01f785218
Document Type :
article
Full Text :
https://doi.org/10.3390/membranes12030283