P1.09 MILD COGNITIVE IMPAIRMENT IS ASSOCIATED WITH SYSTEMIC VASCULAR DYSFUNCTION

Aim: To evaluate vascular function and structure in subjects with mild cognitive impairment (MCI). Methods: 58 MCI and 22 controls (age 74±5vs75±4years, men 45vs59% p=ns) were recruited. Endothelial function in the brachial artery (BA) was studied by flow-mediated dilation (FMD) and response to glyceryl trinitrate, (GTN), while large artery stiffness was measured as carotid-femoral pulse wave velocity (PWV). Results: MCI and controls had a similar prevalence of established CV disease (14vs13%,p=ns) and traditional CV risk factors (hypertension 50vs54%, diabetes 13vs5%, dyslipidemia 28vs48%, smoking 4vs9%, p=ns for all). MCI showed higher blood pressure (BP) values than controls (pulse pressure 70±16vs62±12mmHg, mean BP 97±9vs91±8 mmHg, p