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Pan-cancer screening by circulating tumor DNA (ctDNA) – recent breakthroughs and chronic pitfalls
- Source :
- Journal of Laboratory Medicine, Vol 46, Iss 4, Pp 247-253 (2022)
- Publication Year :
- 2022
- Publisher :
- De Gruyter, 2022.
-
Abstract
- Early detection is crucial for optimal treatment and prognosis of cancer. New approaches for pan-cancer screening comprise the comprehensive characterization of circulating tumor DNA (ctDNA) in plasma by next generation sequencing and molecular profiling of mutations and methylation patterns, as well as fragmentation analysis. These promise the accurate detection and localization of multiple cancers in early disease stages. However, studies with real screening populations have to show their clinical utility and practicability.
Details
- Language :
- English
- ISSN :
- 25679430 and 25679449
- Volume :
- 46
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8d665e2db8654ff1bc5b2e52ca4fdc8d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/labmed-2022-0029