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Precision medicine in neurodegeneration: the IHI-PROMINENT project

Authors :
Ashley Tate
Marc Suárez-Calvet
Mats Ekelund
Sven Eriksson
Maria Eriksdotter
Wiesje M. Van Der Flier
Jean Georges
Miia Kivipelto
Milica G. Kramberger
Peter Lindgren
Juan Domingo Gispert López
Jyrki Lötjönen
Sofie Persson
Sandra Pla
Alina Solomon
Lennart Thurfjell
Anders Wimo
Bengt Winblad
Linus Jönsson
on behalf of the PROMINENT consortium
Source :
Frontiers in Neurology, Vol 14 (2023)
Publication Year :
2023
Publisher :
Frontiers Media S.A., 2023.

Abstract

Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Recent advances in diagnostics and approval for new pharmaceutical treatments for Alzheimer’s disease (AD), the most common etiology of dementia, heralds the beginning of precision medicine in this field. However, their implementation will challenge an already over-burdened healthcare systems. There is a need for innovative digital solutions that can drive the related clinical pathways and optimize and personalize care delivery. Public-private partnerships are ideal vehicles to tackle these challenges. Here we describe the Innovative Health Initiative (IHI) public-private partnership project PROMINENT that has been initiated by connecting leading dementia researchers, medical professionals, dementia patients and their care partners with the latest innovative health technologies using a precision medicine based digital platform. The project builds upon the knowledge and already implemented digital tools from several collaborative initiatives that address new models for early detection, diagnosis, and monitoring of AD and other neurodegenerative disorders. The project aims to provide support to improvement efforts to each aspect of the care pathway including diagnosis, prognosis, treatment, and data collection for real world evidence and cost effectiveness studies. Ultimately the PROMINENT project is expected to lead to cost-effective care and improved health outcomes.

Details

Language :
English
ISSN :
16642295
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Frontiers in Neurology
Publication Type :
Academic Journal
Accession number :
edsdoj.8d18cf280d3344c9a30621b4dcd27bc6
Document Type :
article
Full Text :
https://doi.org/10.3389/fneur.2023.1175922