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Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time

Authors :
Giuseppe Gianini Figueirêdo Leite
Milena Karina Colo Brunialti
Paula M. Peçanha-Pietrobom
Paulo R. Abrão Ferreira
Jaquelina Sonoe Ota-Arakaki
Edecio Cunha-Neto
Bianca Lima Ferreira
Graziella E. Ronsein
Alexandre Keiji Tashima
Reinaldo Salomão
Source :
iScience, Vol 26, Iss 10, Pp 107824- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Summary: The clinical presentation of COVID-19 is highly variable, and understanding the underlying biological processes is crucial. This study utilized a proteomic analysis to investigate dysregulated processes in the peripheral blood mononuclear cells of patients with COVID-19 compared to healthy volunteers. Samples were collected at different stages of the disease, including hospital admission, after 7 days of hospitalization, and 30 days after discharge. Metabolic pathway alterations and increased abundance of neutrophil-related proteins were observed in patients. Patients progressing to critical illness had significantly low-abundance proteins in the pentose phosphate and glycolysis pathways compared with those presenting clinical recovery. Important biological processes, such as fatty acid concentration and glucose metabolism disorder, remained altered even after 30 days of hospital discharge. Temporal proteomic changes revealed distinct pathways in critically ill and non-critically ill patients. Our study emphasizes the significance of longitudinal cellular proteomic studies in identifying disease progression-related pathways and persistent protein changes post-hospitalization.

Details

Language :
English
ISSN :
25890042
Volume :
26
Issue :
10
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.8c95e463be44445bc79391b9090647a
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2023.107824