Advances in clinical diagnosis of Cushing's disease

Cushing's disease, also known as pituitary adrenocorticotrophin⁃secreting adenoma, is a rare and serious neuroendocrine disease. At present, the diagnosis of disease is mainly based on the patient's clinical manifestations, imaging examinations and endocrine ⁃ related examinations. With the development of imaging technology, the refinement of laboratory tests and the maturation of genomics technology, the diagnostic level of the Cushing's disease has improved significantly. This article will review recent research advances on the qualitative and localized diagnosis of Cushing's disease in clinical manifestations, biochemical detection, imaging diagnostics, molecular markers and genomics detection. DOI：10.3969/j.issn.1672⁃6731.2020.03.006