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Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects
- Source :
- International Journal of Endocrinology, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- The association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied yet. The aim of the study is the assessment of plasma zonulin, haptoglobin and proinflammatory cytokines (TNF-α and IL-6) levels in relation to composition of gut microbiota in obese and normal weight subjects. Circulating inflammation markers, such as TNF-α, sTNFR1, sTNFR2, IL-6, zonulin, and haptoglobin levels were measured and semiquantitative analysis of gut microbiota composition was carried out in 50 obese and 30 normal weight subjects without concomitant diseases. Higher circulating zonulin, TNF-α, sTNFR1, sTNFR2, and IL-6 levels were found in the obese subjects. Plasma zonulin level correlated positively with age (r=0.43, P
- Subjects :
- Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Subjects
Details
- Language :
- English
- ISSN :
- 16878337 and 16878345
- Volume :
- 2013
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8c71284ee0ed4739a0ce910d5e7912bb
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2013/674106