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Obesity and leptin in breast cancer angiogenesis

Authors :
Courtney B. Lagarde
Kapil Thapa
Nicole M. Cullen
Mackenzie L. Hawes
Khudeja Salim
Megan C. Benz
Sophie R. Dietrich
Brandon E. Burow
Bruce A. Bunnell
Elizabeth C. Martin
Bridgette M. Collins-Burow
Ronald M. Lynch
Van T. Hoang
Matthew E. Burow
Jennifer S. Fang
Source :
Frontiers in Endocrinology, Vol 15 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.

Details

Language :
English
ISSN :
16642392
Volume :
15
Database :
Directory of Open Access Journals
Journal :
Frontiers in Endocrinology
Publication Type :
Academic Journal
Accession number :
edsdoj.8c40480bd5c346848422b3c98f3422ce
Document Type :
article
Full Text :
https://doi.org/10.3389/fendo.2024.1465727