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Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

Authors :
Kanchan Bisht
Kenneth A. Okojie
Kaushik Sharma
Dennis H. Lentferink
Yu-Yo Sun
Hong-Ru Chen
Joseph O. Uweru
Saipranusha Amancherla
Zainab Calcuttawala
Antony Brayan Campos-Salazar
Bruce Corliss
Lara Jabbour
Jordan Benderoth
Bria Friestad
William A. Mills
Brant E. Isakson
Marie-Ève Tremblay
Chia-Yi Kuan
Ukpong B. Eyo
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular tone via PANX1-P2RY12 signalling.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8c3b78ae6a934bf382bdde9f4a4a758d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25590-8