Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelli var. conescens

Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi. The overall activity of one of them 2-hydroxy-2,6,10-trimethyl-7,10-epoxydodeca- 3,11-dien-5-on, was comparable to that of the antibiotic bifonazole.