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Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes

Authors :
Yuuta Imoto
Yuichi Abe
Masanori Honsho
Kanji Okumoto
Mio Ohnuma
Haruko Kuroiwa
Tsuneyoshi Kuroiwa
Yukio Fujiki
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Mitochondria and peroxisomes require a dynamin-like GTPase to remodel membranes during division. Here the authors identify DYNAMO1, a nucleoside diphosphate kinase-like protein that generates a local source of GTP to promote constriction of the division machinery and produce daughter organelles.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.8b93f747c802479797d6e341c8b1981c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-07009-z