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Bioassay protocol metadata annotation: Proposed standards adoption

Authors :
Rama Balakrishnan
Ellen L. Berg
Christopher C. Butler
Alex M. Clark
Sheryl P. Denker
Isabella Feierberg
Jason Harris
Timothy P. Ikeda
Samantha Jeschonek
Vladimir A. Makarov
Christopher Southan
Dana Vanderwall
Peter Winstanley
Source :
SLAS Discovery, Vol 29, Iss 8, Pp 100188- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

We present a standardized metadata template for assays used in pharmaceutical drug discovery research, according to the FAIR principles. We also describe the use of an automated tool for annotating assays from a variety of sources, including PubChem, commercial assay providers, and the peer-reviewed literature, to this metadata template. Adoption of a standardized metadata template will allow drug discovery scientists to better understand and compare the increasing amounts of assay data becoming available, and will facilitate the use of artificial intelligence tools and other computational methods for analysis and prediction. Since bioassays drive advances in biomedical research, improvements in assay metadata can improve productivity in discovery of new therapeutics, platform technologies, and assay methods.

Details

Language :
English
ISSN :
24725552
Volume :
29
Issue :
8
Database :
Directory of Open Access Journals
Journal :
SLAS Discovery
Publication Type :
Academic Journal
Accession number :
edsdoj.8b7a8009037942d7bdea6491991dfffb
Document Type :
article
Full Text :
https://doi.org/10.1016/j.slasd.2024.100188