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The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Authors :
Yan-yan Yan
Wen-min Zhou
Yu-qing Wang
Qiao-ru Guo
Fu-xi Zhao
Zhuang-yan Zhu
Yan-xia Xing
Hai-yan Zhang
Mohamad Aljofan
Alireza Mosavi Jarrahi
Bolat Makabel
Jian-ye Zhang
Source :
Frontiers in Molecular Biosciences, Vol 8 (2021)
Publication Year :
2021
Publisher :
Frontiers Media S.A., 2021.

Abstract

SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

Details

Language :
English
ISSN :
2296889X
Volume :
8
Database :
Directory of Open Access Journals
Journal :
Frontiers in Molecular Biosciences
Publication Type :
Academic Journal
Accession number :
edsdoj.8b4e1f52be954e5887065c5a154b5297
Document Type :
article
Full Text :
https://doi.org/10.3389/fmolb.2021.699929