Back to Search Start Over

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

Authors :
Yashumati Ratan
Aishwarya Rajput
Ashutosh Pareek
Aaushi Pareek
Ranjeet Kaur
Sonia Sonia
Rahul Kumar
Gurjit Singh
Source :
Biomedicines, Vol 12, Iss 7, p 1390 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Diabetic neuropathy (DN) is a neurodegenerative disorder that is primarily characterized by distal sensory loss, reduced mobility, and foot ulcers that may potentially lead to amputation. The multifaceted etiology of DN is linked to a range of inflammatory, vascular, metabolic, and other neurodegenerative factors. Chronic inflammation, endothelial dysfunction, and oxidative stress are the three basic biological changes that contribute to the development of DN. Although our understanding of the intricacies of DN has advanced significantly over the past decade, the distinctive mechanisms underlying the condition are still poorly understood, which may be the reason behind the lack of an effective treatment and cure for DN. The present study delivers a comprehensive understanding and highlights the potential role of the several pathways and molecular mechanisms underlying the etiopathogenesis of DN. Moreover, Schwann cells and satellite glial cells, as integral factors in the pathogenesis of DN, have been enlightened. This work will motivate allied research disciplines to gain a better understanding and analysis of the current state of the biomolecular mechanisms behind the pathogenesis of DN, which will be essential to effectively address every facet of DN, from prevention to treatment.

Details

Language :
English
ISSN :
12071390 and 22279059
Volume :
12
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
edsdoj.8b3b8bed5955459a918ededa12fee4de
Document Type :
article
Full Text :
https://doi.org/10.3390/biomedicines12071390