Back to Search
Start Over
The importance of central airway dilatation in patients with bronchiolitis obliterans
- Source :
- ERJ Open Research, Vol 7, Iss 4 (2021)
- Publication Year :
- 2021
- Publisher :
- European Respiratory Society, 2021.
-
Abstract
- Background Bronchiolitis obliterans (BO) is a clinical syndrome characterised by progressive small airway obstruction, causing significant morbidity and mortality. Central airway dilatation is one of its radiological characteristics, but little is known about the clinical and pathological associations between airway dilatation and BO. Methods This retrospective study consecutively included patients who underwent lung transplantation due to BO at Kyoto University Hospital from 2009 to 2019. Demographic and histopathological findings of the resected lungs were compared between patients with and without airway dilatation measured by chest computed tomography (CT) at registration for lung transplantation. Results Of a total of 38 included patients (median age, 30 years), 34 (89%) had a history of hematopoietic stem-cell transplantation, and 22 (58%) had airway dilatation based on CT. Patients with airway dilatation had a higher frequency of Pseudomonas aeruginosa isolation with greater residual volume than those without airway dilatation. Quantitative CT analysis revealed an increase in lung volume to predictive total lung capacity and a percentage of low attenuation volume
- Subjects :
- Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 23120541
- Volume :
- 7
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- ERJ Open Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8b0c20ba24da4ee5a0dc4b1555114d5e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1183/23120541.00123-2021