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Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?
- Source :
- mBio, Vol 14, Iss 1 (2023)
- Publication Year :
- 2023
- Publisher :
- American Society for Microbiology, 2023.
-
Abstract
- ABSTRACT Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10.1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear. In vivo and in vitro models are useful to study these important questions and may reveal important differences among SARS-CoV-2 variants in their neuroinvasive, neurotropic, and neurovirulent potential. In this commentary we address how this study contributes to the understanding of the neuropathology of SARS-CoV-2 and its variants.
Details
- Language :
- English
- ISSN :
- 21507511
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- mBio
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8ae2e3e3feb1415ba71b4df088e3873d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1128/mbio.02920-22