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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The success of HER2-targeted cancer therapy is limited by treatment resistance. Here, the authors engineer an anti-HER2 biparatopic antibody with multiple mechanisms of action including induction of HER2 clustering to trigger complement dependent cytotoxicity, signal inhibition, antibody dependent cellular cytotoxicity and phagocytosis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 83249222
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8a871ad93e594eeba832492229b1329b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-37029-3