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Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- Ribosome-associated quality control (RQC) pathways monitor and respond to stalling of the translating ribosome. Here the authors show that the ribosome associated RQC factor Hel2/ZNF598, an E3 ubiquitin ligase, generally interacts with mRNAs in the vicinity of stop codons.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8a7d0af30df44875ade6bb5b790e906b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-08382-z