Back to Search Start Over

Decoy Technology as a Promising Therapeutic Tool for Atherosclerosis

Authors :
Maryam Mahjoubin-Tehran
Yong Teng
Amin Jalili
Seyed Hamid Aghaee-Bakhtiari
Alexander M. Markin
Amirhossein Sahebkar
Source :
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4420 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Cardiovascular diseases (CVDs) have been classified into several types of disease, of which atherosclerosis is the most prevalent. Atherosclerosis is characterized as an inflammatory chronic disease which is caused by the formation of lesions in the arterial wall. Subsequently, lesion progression and disruption ultimately lead to heart disease and stroke. The development of atherosclerosis is the underlying cause of approximately 50% of all deaths in westernized societies. Countless studies have aimed to improve therapeutic approaches for atherosclerosis treatment; however, it remains high on the global list of challenges toward healthy and long lives. Some patients with familial hypercholesterolemia could not get intended LDL-C goals even with high doses of traditional therapies such as statins, with many of them being unable to tolerate statins because of the harsh side effects. Furthermore, even in patients achieving target LDL-C levels, the residual risk of traditional therapies is still significant thus highlighting the necessity of ongoing research for more effective therapeutic approaches with minimal side effects. Decoy-based drug candidates represent an opportunity to inhibit regulatory pathways that promote atherosclerosis. In this review, the potential roles of decoys in the treatment of atherosclerosis were described based on the in vitro and in vivo findings.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
22
Issue :
9
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.8a7a701e930f4414ac21471c0bd4b264
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms22094420