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Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis

Authors :
Chang Liu
Jin Liu
Tongtong Wang
Yang Su
Lei Li
Miaomiao Lan
Yingying Yu
Fan Liu
Lei Xiong
Kun Wang
Meijing Chen
Na Li
Qing Xu
Yue Hu
Yuxin Jia
Qingyong Meng
Source :
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10008 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Brown adipose tissue (BAT) is functionally linked to skeletal muscle because both tissues originate from a common progenitor cell, but the precise mechanism controlling muscle-to-brown-fat communication is insufficiently understood. This report demonstrates that the immunoglobulin superfamily containing leucine-rich repeat (Islr), a marker of mesenchymal stromal/stem cells, is critical for the control of BAT mitochondrial function and whole-body energy homeostasis. The mice loss of Islr in BAT after cardiotoxin injury resulted in improved mitochondrial function, increased energy expenditure, and enhanced thermogenesis. Importantly, it was found that interleukin-6 (IL-6), as a myokine, participates in this process. Mechanistically, Islr interacts with NADH: Ubiquinone Oxidoreductase Core Subunit S2 (Ndufs2) to regulate IL-6 signaling; consequently, Islr functions as a brake that prevents IL-6 from promoting BAT activity. Together, these findings reveal a previously unrecognized mechanism for muscle-BAT cross talk driven by Islr, Ndufs2, and IL-6 to regulate energy homeostasis, which may be used as a potential therapeutic target in obesity.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
23
Issue :
17
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.8a6256d0daec493d9ba6af877c7ab7bf
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms231710008