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Albumin-to-protein ratio in spot urine samples for analysis of proteinuria selectivity in chronic kidney disease
- Source :
- Brazilian Journal of Nephrology (2022)
- Publication Year :
- 2022
- Publisher :
- Sociedade Brasileira de Nefrologia, 2022.
-
Abstract
- ABSTRACT Introduction: The albumin-to-creatinine ratio and total protein-to-creatinine ratio in spot urine samples have already been validated as surrogates for 24-hour albuminuria and proteinuria measurements. Thus, we hypothesized that the type of proteinuria, detected by the electrophoretic pattern of 24-hour urine, could be predicted by the simple proportion of albumin in the total urine protein content, using the albumin-to-protein ratio (APR). Our study sought to validate the use of APR as a cheaper substitute for urinary protein electrophoresis (UPE). Methods: Using different mathematical models, we compared, the albumin fraction in 24-hour urine samples by electrophoresis and the APR ratio in spot samples from 42 outpatients with chronic kidney disease (CKD). Results: A strong log-order correlation r = 0.84 (0.75–0.92; 95% CI, p = 0.001) was observed between APR and the albumin fraction in the UPE. Conclusion: The APR can substitute electrophoresis in CKD outpatients.
Details
- Language :
- English, Portuguese
- ISSN :
- 21758239
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.8a5e91a5fc2b4460842a22f0ba498a33
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/2175-8239-jbn-2022-0079en